| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/31/2010 | BBS | Happ | Acquired via trade | TTP | | After |
| 3/31/2010 | BBS | Harrison | Traded away | DVD | | After |
| 3/31/2010 | BBS | Hughes,P | Traded away | TTP | | After |
| 3/31/2010 | BBS | Johjima | Traded away | DDC | | After |
| 3/31/2010 | BBS | Lewis,J | Acquired via trade | DVD | | After |
| 3/31/2010 | BBS | Ortiz,R | Traded away | TTP | | After |
| 3/31/2010 | BBS | Seay | Traded away | LA | | After |
| 3/31/2010 | BBS | Todd | Acquired via trade | DVD | | After |
| 3/31/2010 | BBZ | Hendrickson | Traded away | TTP | | After |
| 3/31/2010 | BBZ | Infante | Acquired via trade | TTP | | After |
| 3/31/2010 | BBZ | Valdez,W | Traded away | TTP | | After |
| 3/31/2010 | DB | Chavez,R | Traded away | RP | | After |
| 3/31/2010 | DB | Hoffpauir,M | Acquired via trade | RP | | After |
| 3/31/2010 | DDC | Alfonzo | Acquired via trade | PHR | | After |
| 3/31/2010 | DDC | Barden | Traded away | RP | | After |
| 3/31/2010 | DDC | Burton | Traded away | TTP | | After |
| 3/31/2010 | DDC | Carlson | Acquired via trade | RP | | After |
| 3/31/2010 | DDC | Davis,R | Acquired via trade | TTP | | After |
| 3/31/2010 | DDC | Frasor | Acquired via trade | TTP | | After |
| 3/31/2010 | DDC | Gload | Traded away | PHR | | After |
| 3/31/2010 | DDC | Hinske | Acquired via trade | RP | | After |
| 3/31/2010 | DDC | Inge | Acquired via trade | PHR | | After |
| 3/31/2010 | DDC | Jackson,C | Traded away | TTP | | After |
| 3/31/2010 | DDC | Johjima | Acquired via trade | BBS | | After |
| 3/31/2010 | DDC | Johnson,Ra | Traded away | RP | | After |
| 3/31/2010 | DDC | Marmol | Traded away | PHR | | After |
| 3/31/2010 | DDC | Murphy,Dav | Acquired via trade | LA | | After |
| 3/31/2010 | DDC | Ohlendorf | Traded away | LA | | After |
| 3/31/2010 | DDC | Pelfrey | Acquired via trade | LA | | After |
| 3/31/2010 | DDC | Purcey | Acquired via trade | LA | | After |
| 3/31/2010 | DDC | Snell | Acquired via trade | RP | | After |
| 3/31/2010 | DDC | Sweeney,M | Traded away | PHR | | After |
| 3/31/2010 | DDC | Venable | Traded away | TTP | | After |
| 3/31/2010 | DF | Baldelli | Acquired via trade | RP | | After |
| 3/31/2010 | DF | Joyce | Acquired via trade | RP | | After |
| 3/31/2010 | DVD | Anderson,Bri | Traded away | GC | | After |
| 3/31/2010 | DVD | Gathright | Traded away | Ven | | After |
| 3/31/2010 | DVD | Guerrier | Acquired via trade | GC | | After |
| 3/31/2010 | DVD | Harden | Traded away | SK | | After |
| 3/31/2010 | DVD | Harrison | Acquired via trade | BBS | | After |
| 3/31/2010 | DVD | Iwamura | Acquired via trade | Oak | | After |
| 3/31/2010 | DVD | Keppinger | Traded away | Oak | | After |
| 3/31/2010 | DVD | Lewis,F | Traded away | GC | | After |
| 3/31/2010 | DVD | Lewis,J | Traded away | BBS | | After |
| 3/31/2010 | DVD | Theriot | Traded away | MM | | After |
| 3/31/2010 | DVD | Todd | Traded away | BBS | | After |
| 3/31/2010 | ER | Gross | Traded away | Rus | | After |
| 3/31/2010 | ER | LeBlanc | Acquired via trade | Rus | | After |
| 3/31/2010 | ER | Mientkiewicz | Traded away | Rus | | After |
| 3/31/2010 | ER | Ni | Acquired via trade | Rus | | After |
| 3/31/2010 | ER | Smoltz | Acquired via trade | Rus | | After |
| 3/31/2010 | ER | Uehara | Acquired via trade | Rus | | After |
| 3/31/2010 | ER | Zito | Traded away | Rus | | After |
| 3/31/2010 | GC | Anderson,Bri | Acquired via trade | DVD | | After |
| 3/31/2010 | GC | Belisle | Acquired via trade | SP | | After |
| 3/31/2010 | GC | Guerrier | Traded away | DVD | | After |
| 3/31/2010 | GC | Inglett | Traded away | SP | | After |
| 3/31/2010 | GC | Isringhausen | Traded away | SP | | After |
| 3/31/2010 | GC | Lewis,F | Acquired via trade | DVD | | After |
| 3/31/2010 | GC | Linebrink | Acquired via trade | RP | | After |
| 3/31/2010 | GC | Myers | Acquired via trade | RP | | After |
| 3/31/2010 | GC | Ohka | Acquired via trade | SP | | After |
| 3/31/2010 | GC | Palmer | Traded away | RP | | After |
| 3/31/2010 | GC | Wang | Acquired via trade | SP | | After |
| 3/31/2010 | KCR | Feliciano | Traded away | PHR | | After |
| 3/31/2010 | KCR | Feliciano | Traded away | PHR | | After |
| 3/31/2010 | KCR | Feliciano | Acquired via trade | PHR | | After |
| 3/31/2010 | KCR | Howell | Acquired via trade | SP | | After |
| 3/31/2010 | KCR | Schlereth | Acquired via trade | SP | | After |
| 3/31/2010 | KCR | Sherrill | Traded away | SP | | After |
| 3/31/2010 | KCR | Ziegler | Traded away | PHR | | After |
| 3/31/2010 | KCR | Ziegler | Acquired via trade | PHR | | After |
| 3/31/2010 | KCR | Ziegler | Acquired via trade | PHR | | After |
| 3/31/2010 | LA | Montanez | Acquired via trade | Rus | | After |
| 3/31/2010 | LA | Murphy,Dav | Traded away | DDC | | After |
| 3/31/2010 | LA | Murphy,Dav | Acquired via trade | Rus | | After |
| 3/31/2010 | LA | Ohlendorf | Acquired via trade | DDC | | After |
| 3/31/2010 | LA | Pelfrey | Traded away | DDC | | After |
| 3/31/2010 | LA | Pelfrey | Acquired via trade | Rus | | After |
| 3/31/2010 | LA | Purcey | Traded away | DDC | | After |
| 3/31/2010 | LA | Purcey | Acquired via trade | Rus | | After |
| 3/31/2010 | LA | Seay | Acquired via trade | BBS | | After |
| 3/31/2010 | LA | Wolf | Traded away | Rus | | After |
| 3/31/2010 | LC | McCutchen,D | Traded away | Rus | | After |
| 3/31/2010 | MM | Gonzalez,EV | Acquired via trade | RP | | After |
| 3/31/2010 | MM | Miller,C | Traded away | RP | | After |
| 3/31/2010 | MM | Theriot | Acquired via trade | DVD | | After |
| 3/31/2010 | Oak | Iwamura | Traded away | DVD | | After |
| 3/31/2010 | Oak | Keppinger | Acquired via trade | DVD | | After |
| 3/31/2010 | PHR | Alfonzo | Traded away | DDC | | After |
| 3/31/2010 | PHR | Feliciano | Traded away | KCR | | After |
| 3/31/2010 | PHR | Feliciano | Acquired via trade | KCR | | After |
| 3/31/2010 | PHR | Feliciano | Acquired via trade | KCR | | After |
| 3/31/2010 | PHR | Gload | Acquired via trade | DDC | | After |
| 3/31/2010 | PHR | Inge | Traded away | DDC | | After |
| 3/31/2010 | PHR | Marmol | Acquired via trade | DDC | | After |
| 3/31/2010 | PHR | Sweeney,M | Acquired via trade | DDC | | After |
| 3/31/2010 | PHR | Ziegler | Traded away | KCR | | After |
| 3/31/2010 | PHR | Ziegler | Traded away | KCR | | After |
| 3/31/2010 | PHR | Ziegler | Acquired via trade | KCR | | After |
| 3/31/2010 | RP | Baldelli | Traded away | DF | | After |
| 3/31/2010 | RP | Barden | Acquired via trade | DDC | | After |
| 3/31/2010 | RP | Barfield | Acquired via trade | SF | | After |
| 3/31/2010 | RP | Carlson | Traded away | DDC | | After |
| 3/31/2010 | RP | Chavez,R | Acquired via trade | DB | | After |
| 3/31/2010 | RP | Fuentes | Acquired via trade | SK | | After |
| 3/31/2010 | RP | Gonzalez,EV | Traded away | MM | | After |
| 3/31/2010 | RP | Hinske | Traded away | DDC | | After |
| 3/31/2010 | RP | Hoffpauir,M | Traded away | DB | | After |
| 3/31/2010 | RP | Johnson,Ra | Traded away | SK | | After |
| 3/31/2010 | RP | Johnson,Ra | Acquired via trade | DDC | | After |
| 3/31/2010 | RP | Joyce | Traded away | DF | | After |
| 3/31/2010 | RP | Linebrink | Traded away | GC | | After |
| 3/31/2010 | RP | Miller,C | Traded away | SF | | After |
| 3/31/2010 | RP | Miller,C | Acquired via trade | MM | | After |
| 3/31/2010 | RP | Myers | Traded away | GC | | After |
| 3/31/2010 | RP | Palmer | Acquired via trade | GC | | After |
| 3/31/2010 | RP | Snell | Traded away | DDC | | After |
| 3/31/2010 | Rus | Gross | Acquired via trade | ER | | After |
| 3/31/2010 | Rus | LeBlanc | Traded away | ER | | After |
| 3/31/2010 | Rus | McCutchen,D | Acquired via trade | LC | | After |
| 3/31/2010 | Rus | Mientkiewicz | Acquired via trade | ER | | After |
| 3/31/2010 | Rus | Montanez | Traded away | LA | | After |
| 3/31/2010 | Rus | Murphy,Dav | Traded away | LA | | After |
| 3/31/2010 | Rus | Ni | Traded away | ER | | After |
| 3/31/2010 | Rus | Pelfrey | Traded away | LA | | After |
| 3/31/2010 | Rus | Purcey | Traded away | LA | | After |
| 3/31/2010 | Rus | Smoltz | Traded away | ER | | After |
| 3/31/2010 | Rus | Uehara | Traded away | ER | | After |
| 3/31/2010 | Rus | Wolf | Acquired via trade | LA | | After |
| 3/31/2010 | Rus | Zito | Acquired via trade | ER | | After |
| 3/31/2010 | SF | Barfield | Traded away | RP | | After |
| 3/31/2010 | SF | Miller,C | Acquired via trade | RP | | After |
| 3/31/2010 | SK | Fuentes | Traded away | RP | | After |
| 3/31/2010 | SK | Harden | Acquired via trade | DVD | | After |
| 3/31/2010 | SK | Johnson,Ra | Acquired via trade | RP | | After |
| 3/31/2010 | SP | Belisle | Traded away | GC | | After |
| 3/31/2010 | SP | Howell | Traded away | KCR | | After |
| 3/31/2010 | SP | Inglett | Acquired via trade | GC | | After |
| 3/31/2010 | SP | Isringhausen | Acquired via trade | GC | | After |
| 3/31/2010 | SP | Ohka | Traded away | GC | | After |
| 3/31/2010 | SP | Schlereth | Traded away | KCR | | After |
| 3/31/2010 | SP | Sherrill | Acquired via trade | KCR | | After |
| 3/31/2010 | SP | Wang | Traded away | GC | | After |
| 3/31/2010 | TTP | Burton | Acquired via trade | DDC | | After |
| 3/31/2010 | TTP | Davis,R | Traded away | DDC | | After |
| 3/31/2010 | TTP | Frasor | Traded away | DDC | | After |
| 3/31/2010 | TTP | Happ | Traded away | BBS | | After |
| 3/31/2010 | TTP | Hendrickson | Acquired via trade | BBZ | | After |
| 3/31/2010 | TTP | Hughes,P | Acquired via trade | BBS | | After |
| 3/31/2010 | TTP | Infante | Traded away | BBZ | | After |
| 3/31/2010 | TTP | Jackson,C | Acquired via trade | DDC | | After |
| 3/31/2010 | TTP | Ortiz,R | Acquired via trade | BBS | | After |
| 3/31/2010 | TTP | Valdez,W | Acquired via trade | BBZ | | After |
| 3/31/2010 | TTP | Venable | Acquired via trade | DDC | | After |
| 3/31/2010 | Ven | Gathright | Acquired via trade | DVD | | After |
| 5/14/2010 | BBZ | Barton,B | Released | | | Before |
| 5/14/2010 | BBZ | Carrasco,D | Demoted to reserve roster | | | Before |
| 5/14/2010 | BBZ | Wood,K | Demoted to reserve roster | | | Before |
| 5/14/2010 | BBZ | Masset | Acquired via trade | TTP | | After |
| 5/14/2010 | BBZ | O'Day | Acquired via trade | TTP | | After |
| 5/14/2010 | BBZ | Sampson | Traded away | TTP | | After |
| 5/14/2010 | Cal | Colon,B | Demoted to reserve roster | | | Before |
| 5/14/2010 | Cal | Harris,W | Demoted to reserve roster | | | Before |
| 5/14/2010 | Cal | Moehler | Promoted to active roster | | | Before |
| 5/14/2010 | Cal | Monroe | Promoted to active roster | | | Before |
| 5/14/2010 | Cal | Penny | Promoted to active roster | | | Before |
| 5/14/2010 | Cal | Smith,Jo | Demoted to reserve roster | | | Before |
| 5/14/2010 | DB | Buckner | Promoted to active roster | | | Before |
| 5/14/2010 | DB | Cunningham | Demoted to reserve roster | | | Before |
| 5/14/2010 | DB | Davis,W | Promoted to active roster | | | Before |
| 5/14/2010 | DB | Perry | Demoted to reserve roster | | | Before |
| 5/14/2010 | DB | Romo | Promoted to active roster | | | Before |
| 5/14/2010 | DB | Sadowski | Demoted to reserve roster | | | Before |
| 5/14/2010 | DB | Stults | Demoted to reserve roster | | | Before |
| 5/14/2010 | ER | Bruntlett | Promoted to active roster | | | Before |
| 5/14/2010 | ER | Crowe | Promoted to active roster | | | Before |
| 5/14/2010 | ER | Jones,An | Demoted to reserve roster | | | Before |
| 5/14/2010 | ER | Linebrink | Signed | | | Before |
| 5/14/2010 | ER | Mazzaro | Promoted to active roster | | | Before |
| 5/14/2010 | ER | Nix,L | Demoted to reserve roster | | | Before |
| 5/14/2010 | ER | Uehara | Demoted to reserve roster | | | Before |
| 5/14/2010 | ER | Ni | Traded away | SP | | After |
| 5/14/2010 | KCR | Belisario | Traded away | LA | | After |
| 5/14/2010 | KCR | Cameron,K | Acquired via trade | LA | | After |
| 5/14/2010 | KCR | Carroll,J | Acquired via trade | LA | | After |
| 5/14/2010 | KCR | Hawksworth | Traded away | LA | | After |
| 5/14/2010 | KCR | Michaels | Acquired via trade | LA | | After |
| 5/14/2010 | KCR | Miller,T | Traded away | LA | | After |
| 5/14/2010 | LA | DiFelice | Demoted to reserve roster | | | Before |
| 5/14/2010 | LA | Gray | Demoted to reserve roster | | | Before |
| 5/14/2010 | LA | Hawksworth | Demoted to reserve roster | | | Before |
| 5/14/2010 | LA | Belisario | Acquired via trade | KCR | | After |
| 5/14/2010 | LA | Cameron,K | Traded away | KCR | | After |
| 5/14/2010 | LA | Carroll,J | Traded away | KCR | | After |
| 5/14/2010 | LA | Hawksworth | Acquired via trade | KCR | | After |
| 5/14/2010 | LA | Michaels | Traded away | KCR | | After |
| 5/14/2010 | LA | Miller,T | Acquired via trade | KCR | | After |
| 5/14/2010 | LC | Evans,N | Demoted to reserve roster | | | Before |
| 5/14/2010 | LC | Ramirez,Ho | Promoted to active roster | | | Before |
| 5/14/2010 | MM | Aviles | Demoted to reserve roster | | | Before |
| 5/14/2010 | MM | Carlin | Demoted to reserve roster | | | Before |
| 5/14/2010 | MM | Hernandez,R | Demoted to reserve roster | | | Before |
| 5/14/2010 | MM | Jackson,Z | Demoted to reserve roster | | | Before |
| 5/14/2010 | MM | Langerhans | Demoted to reserve roster | | | Before |
| 5/14/2010 | MM | Lehr | Demoted to reserve roster | | | Before |
| 5/14/2010 | MM | Maxwell | Demoted to reserve roster | | | Before |
| 5/14/2010 | MM | Richar | Demoted to reserve roster | | | Before |
| 5/14/2010 | MM | Rodriguez,R | Demoted to reserve roster | | | Before |
| 5/14/2010 | MM | Wolfe | Demoted to reserve roster | | | Before |
| 5/14/2010 | SP | Geary | Released | | | Before |
| 5/14/2010 | SP | Ni | Acquired via trade | ER | | After |
| 5/14/2010 | TTP | Stavinoha | Signed | | | Before |
| 5/14/2010 | TTP | Masset | Traded away | BBZ | | After |
| 5/14/2010 | TTP | O'Day | Traded away | BBZ | | After |
| 5/14/2010 | TTP | Sampson | Acquired via trade | BBZ | | After |
| 5/14/2010 | WSC | Arredondo | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Bennett | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Bush | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Cecil | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Gorzelanny | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Laffey | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Laffey | Promoted to active roster | | | Before |
| 5/14/2010 | WSC | Laffey | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Laffey | Promoted to active roster | | | Before |
| 5/14/2010 | WSC | Macias | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Niese | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Niese | Promoted to active roster | | | Before |
| 5/14/2010 | WSC | Nieve | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Nieve | Promoted to active roster | | | Before |
| 5/14/2010 | WSC | Nieve | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Perez,R | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Perkins | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Perkins | Promoted to active roster | | | Before |
| 5/14/2010 | WSC | Perkins | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Perkins | Promoted to active roster | | | Before |
| 5/14/2010 | WSC | Perkins | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Sowers | Demoted to reserve roster | | | Before |
| 5/14/2010 | WSC | Thole | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Amezaga | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Burns | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Embree | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Gervacio | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Glaus | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Hill,S | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Orr | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Ryan,BJ | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Sammons | Demoted to reserve roster | | | Before |
| 5/15/2010 | Bos | Toregas | Demoted to reserve roster | | | Before |
| 5/15/2010 | DB | Anderson,J | Demoted to reserve roster | | | Before |
| 5/15/2010 | DB | Brantley | Promoted to active roster | | | Before |
| 5/15/2010 | DB | Cunningham | Promoted to active roster | | | Before |
| 5/15/2010 | DB | Davis,W | Demoted to reserve roster | | | Before |
| 5/15/2010 | DB | Desmond | Promoted to active roster | | | Before |
| 5/15/2010 | DB | French | Promoted to active roster | | | Before |
| 5/15/2010 | DB | Giles | Demoted to reserve roster | | | Before |
| 5/15/2010 | DB | Ponson | Promoted to active roster | | | Before |
| 5/15/2010 | DB | Santana,E | Demoted to reserve roster | | | Before |
| 5/15/2010 | DB | Stults | Promoted to active roster | | | Before |
| 5/15/2010 | DB | Taveras,W | Demoted to reserve roster | | | Before |
| 5/15/2010 | DB | Volstad | Demoted to reserve roster | | | Before |
| 5/15/2010 | DF | Tallet | Demoted to reserve roster | | | Before |
| 5/15/2010 | DF | Weaver,Jef | Promoted to active roster | | | Before |
| 5/15/2010 | GC | Bako | Promoted to active roster | | | Before |
| 5/15/2010 | GC | Belisle | Promoted to active roster | | | Before |
| 5/15/2010 | GC | Milledge | Demoted to reserve roster | | | Before |
| 5/15/2010 | GC | Nady | Demoted to reserve roster | | | Before |
| 5/15/2010 | GC | Springer | Demoted to reserve roster | | | Before |
| 5/15/2010 | GC | Tillman | Demoted to reserve roster | | | Before |
| 5/15/2010 | GC | Wang | Promoted to active roster | | | Before |
| 5/15/2010 | GC | Whitesell | Promoted to active roster | | | Before |
| 5/15/2010 | GC | Whiteside | Demoted to reserve roster | | | Before |
| 5/15/2010 | GC | Woodward | Promoted to active roster | | | Before |
| 5/15/2010 | Sac | Allen | Promoted to active roster | | | Before |
| 5/15/2010 | Sac | Buscher | Promoted to active roster | | | Before |
| 5/15/2010 | Sac | Fox,J | Demoted to reserve roster | | | Before |
| 5/15/2010 | Sac | Green,S | Demoted to reserve roster | | | Before |
| 5/15/2010 | Sac | Kottaras | Demoted to reserve roster | | | Before |
| 5/15/2010 | Sac | Kottaras | Promoted to active roster | | | Before |
| 5/15/2010 | Sac | Meek | Promoted to active roster | | | Before |
| 5/15/2010 | Sac | Quentin | Demoted to reserve roster | | | Before |
| 5/15/2010 | Sac | Villanueva | Demoted to reserve roster | | | Before |
| 5/15/2010 | Sac | Walker,T | Promoted to active roster | | | Before |
| 5/15/2010 | SP | Greene,K | Demoted to reserve roster | | | Before |
| 5/15/2010 | SP | Outman | Promoted to active roster | | | Before |
| 5/15/2010 | SP | Washburn | Demoted to reserve roster | | | Before |
| 5/15/2010 | TTP | Aceves | Demoted to reserve roster | | | Before |
| 5/15/2010 | TTP | Jackson,C | Promoted to active roster | | | Before |
| 5/15/2010 | TTP | Lowrie | Promoted to active roster | | | Before |
| 5/15/2010 | TTP | Ramirez,M | Demoted to reserve roster | | | Before |
| 5/15/2010 | TTP | Redding | Promoted to active roster | | | Before |
| 5/15/2010 | TTP | Sampson | Promoted to active roster | | | Before |
| 5/15/2010 | TTP | Thome | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Arredondo | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Bennett | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Bush | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Cecil | Promoted to active roster | | | Before |
| 5/15/2010 | WSC | Gorzelanny | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Macias | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Niese | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Niese | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Nieve | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Perez,R | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Perkins | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Rivera,Mi | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Rivera,Mi | Demoted to reserve roster | | | Before |
| 5/15/2010 | WSC | Sowers | Promoted to active roster | | | Before |
| 5/15/2010 | WSC | Thole | Promoted to active roster | | | Before |
| 5/19/2010 | Cal | Boggs,M | Demoted to reserve roster | | | Before |
| 5/19/2010 | ER | Ausmus | Demoted to reserve roster | | | Before |
| 5/19/2010 | ER | Bruntlett | Promoted to active roster | | | Before |
| 5/19/2010 | ER | Guillen,J | Demoted to reserve roster | | | Before |
| 5/19/2010 | ER | Jaramillo | Promoted to active roster | | | Before |
| 5/19/2010 | ER | Mahay | Demoted to reserve roster | | | Before |
| 5/19/2010 | ER | Narveson | Promoted to active roster | | | Before |
| 5/24/2010 | Sac | Bruce | Demoted to reserve roster | | | Before |
| 5/24/2010 | Sac | Buscher | Demoted to reserve roster | | | Before |
| 5/24/2010 | Sac | Buscher | Promoted to active roster | | | Before |
| 5/24/2010 | Sac | Fox,J | Promoted to active roster | | | Before |
| 5/24/2010 | Sac | Green,S | Promoted to active roster | | | Before |
| 5/24/2010 | Sac | Gutierrez,J | Demoted to reserve roster | | | Before |
| 5/24/2010 | Sac | Pearce | Demoted to reserve roster | | | Before |
| 5/24/2010 | Sac | Quentin | Promoted to active roster | | | Before |
| 5/24/2010 | Sac | Reyes,JB | Demoted to reserve roster | | | Before |
| 5/24/2010 | Sac | Villanueva | Promoted to active roster | | | Before |
| 5/24/2010 | Sac | Walker,T | Demoted to reserve roster | | | Before |
| 5/24/2010 | Sac | Wood,B | Promoted to active roster | | | Before |
| 5/24/2010 | WSC | Cecil | Demoted to reserve roster | | | Before |
| 5/24/2010 | WSC | Laffey | Demoted to reserve roster | | | Before |
| 5/24/2010 | WSC | Nieve | Promoted to active roster | | | Before |
| 5/24/2010 | WSC | Perkins | Promoted to active roster | | | Before |
| 5/24/2010 | WSC | Sowers | Demoted to reserve roster | | | Before |
| 5/24/2010 | WSC | Sowers | Promoted to active roster | | | Before |
| 5/30/2010 | DF | Miner | Promoted to active roster | | | Before |
| 5/30/2010 | DF | Zaun | Demoted to reserve roster | | | Before |
| 6/5/2010 | Sac | Albers | Promoted to active roster | | | Before |
| 6/5/2010 | Sac | Allen | Demoted to reserve roster | | | Before |
| 6/5/2010 | Sac | Bruce | Promoted to active roster | | | Before |
| 6/5/2010 | Sac | Eyre,S | Demoted to reserve roster | | | Before |
| 6/5/2010 | Sac | Gutierrez,J | Demoted to reserve roster | | | Before |
| 6/5/2010 | Sac | Gutierrez,J | Promoted to active roster | | | Before |
| 6/5/2010 | Sac | Pearce | Promoted to active roster | | | Before |
| 6/5/2010 | Sac | Wood,B | Demoted to reserve roster | | | Before |
| 6/5/2010 | SK | Gonzalez,G | Promoted to active roster | | | Before |
| 6/5/2010 | SK | Johnson,Ra | Demoted to reserve roster | | | Before |
| 6/5/2010 | WSC | Laffey | Promoted to active roster | | | Before |
| 6/5/2010 | WSC | Nieve | Demoted to reserve roster | | | Before |
| 6/11/2010 | DF | Burriss | Promoted to active roster | | | Before |
| 6/11/2010 | DF | Carmona | Demoted to reserve roster | | | Before |
| 6/11/2010 | DF | Guzman,C | Demoted to reserve roster | | | Before |
| 6/11/2010 | DF | Paulino,F | Promoted to active roster | | | Before |
| 6/11/2010 | DF | Silva,C | Promoted to active roster | | | Before |
| 6/11/2010 | DF | Weaver,Jef | Demoted to reserve roster | | | Before |
| 6/11/2010 | Sac | Albers | Demoted to reserve roster | | | Before |
| 6/11/2010 | Sac | Allen | Promoted to active roster | | | Before |
| 6/11/2010 | Sac | Fox,J | Demoted to reserve roster | | | Before |
| 6/11/2010 | Sac | Gutierrez,J | Promoted to active roster | | | Before |
| 6/11/2010 | Sac | Kottaras | Promoted to active roster | | | Before |
| 6/11/2010 | Sac | Pearce | Demoted to reserve roster | | | Before |
| 6/11/2010 | Sac | Reyes,JB | Promoted to active roster | | | Before |
| 6/11/2010 | Sac | Snyder | Demoted to reserve roster | | | Before |
| 6/11/2010 | Sac | Villanueva | Demoted to reserve roster | | | Before |
| 6/11/2010 | Sac | Walker,T | Promoted to active roster | | | Before |
| 6/11/2010 | WSC | Cecil | Promoted to active roster | | | Before |
| 6/11/2010 | WSC | Laffey | Demoted to reserve roster | | | Before |
| 6/11/2010 | WSC | Laffey | Promoted to active roster | | | Before |
| 6/11/2010 | WSC | Perkins | Demoted to reserve roster | | | Before |
| 6/16/2010 | Rus | Donnelly | Promoted to active roster | | | Before |
| 6/16/2010 | Rus | Gordon,A | Demoted to reserve roster | | | Before |
| 6/16/2010 | Rus | Harang | Demoted to reserve roster | | | Before |
| 6/16/2010 | Rus | Hudson,T | Promoted to active roster | | | Before |
| 6/22/2010 | SK | Gonzalez,G | Promoted to active roster | | | Before |
| 6/22/2010 | SK | Johnson,Ra | Demoted to reserve roster | | | Before |
| 6/22/2010 | SP | Outman | Demoted to reserve roster | | | Before |
| 6/22/2010 | SP | Washburn | Promoted to active roster | | | Before |
| 6/28/2010 | DB | Cunningham | Demoted to reserve roster | | | Before |
| 6/28/2010 | DB | Detwiler | Demoted to reserve roster | | | Before |
| 6/28/2010 | DB | Detwiler | Promoted to active roster | | | Before |
| 6/28/2010 | DB | Getz | Demoted to reserve roster | | | Before |
| 6/28/2010 | DB | Giles | Promoted to active roster | | | Before |
| 6/28/2010 | DB | Hanson,T | Demoted to reserve roster | | | Before |
| 6/28/2010 | DB | Hanson,T | Promoted to active roster | | | Before |
| 6/28/2010 | DB | Stults | Demoted to reserve roster | | | Before |
| 6/28/2010 | DB | Stults | Promoted to active roster | | | Before |
| 6/28/2010 | DB | Volstad | Demoted to reserve roster | | | Before |
| 6/28/2010 | DB | Volstad | Promoted to active roster | | | Before |
| 6/28/2010 | DB | Feliz,N | Traded away | SP | | After |
| 6/28/2010 | DB | Sheets | Acquired via trade | SP | | After |
| 6/28/2010 | DVD | Arroyo | Acquired via trade | KCR | | After |
| 6/28/2010 | DVD | Kennedy,A | Traded away | KCR | | After |
| 6/28/2010 | DVD | Kouzmanoff | Acquired via trade | KCR | | After |
| 6/28/2010 | KCR | Arroyo | Traded away | DVD | | After |
| 6/28/2010 | KCR | Kennedy,A | Acquired via trade | DVD | | After |
| 6/28/2010 | KCR | Kouzmanoff | Traded away | DVD | | After |
| 6/28/2010 | KCR | Maine | Acquired via trade | RP | | After |
| 6/28/2010 | KCR | Pineiro | Traded away | RP | | After |
| 6/28/2010 | MM | Figueroa | Demoted to reserve roster | | | Before |
| 6/28/2010 | MM | Gonzalez,EV | Promoted to active roster | | | Before |
| 6/28/2010 | MM | Hernandez,Da | Promoted to active roster | | | Before |
| 6/28/2010 | MM | Hernandez,R | Promoted to active roster | | | Before |
| 6/28/2010 | MM | Lehr | Demoted to reserve roster | | | Before |
| 6/28/2010 | MM | Maxwell | Demoted to reserve roster | | | Before |
| 6/28/2010 | MM | Moseley | Demoted to reserve roster | | | Before |
| 6/28/2010 | MM | Rodriguez,R | Promoted to active roster | | | Before |
| 6/28/2010 | MM | Rodriguez,R | Promoted to active roster | | | Before |
| 6/28/2010 | MM | Romero,J | Demoted to reserve roster | | | Before |
| 6/28/2010 | MM | Romero,J | Demoted to reserve roster | | | Before |
| 6/28/2010 | MM | Wolfe | Promoted to active roster | | | Before |
| 6/28/2010 | PHR | Castillo,L | Traded away | Ven | | After |
| 6/28/2010 | PHR | Conrad | Acquired via trade | Ven | | After |
| 6/28/2010 | PHR | Garko | Traded away | Ven | | After |
| 6/28/2010 | PHR | Hughes,P | Acquired via trade | TTP | | After |
| 6/28/2010 | PHR | Wuertz | Traded away | Ven | | After |
| 6/28/2010 | RP | Aceves | Acquired via trade | TTP | | After |
| 6/28/2010 | RP | Burton | Acquired via trade | TTP | | After |
| 6/28/2010 | RP | Jennings | Acquired via trade | TTP | | After |
| 6/28/2010 | RP | Maine | Traded away | KCR | | After |
| 6/28/2010 | RP | Pineiro | Acquired via trade | KCR | | After |
| 6/28/2010 | RP | Thome | Acquired via trade | TTP | | After |
| 6/28/2010 | SP | Feliz,N | Acquired via trade | DB | | After |
| 6/28/2010 | SP | Sheets | Traded away | DB | | After |
| 6/28/2010 | TTP | Balester | Promoted to active roster | | | Before |
| 6/28/2010 | TTP | Burton | Demoted to reserve roster | | | Before |
| 6/28/2010 | TTP | Gonzalez,EG | Promoted to active roster | | | Before |
| 6/28/2010 | TTP | Jackson,C | Demoted to reserve roster | | | Before |
| 6/28/2010 | TTP | Lowrie | Demoted to reserve roster | | | Before |
| 6/28/2010 | TTP | Morton | Demoted to reserve roster | | | Before |
| 6/28/2010 | TTP | Stavinoha | Demoted to reserve roster | | | Before |
| 6/28/2010 | TTP | Aceves | Traded away | RP | | After |
| 6/28/2010 | TTP | Burton | Traded away | RP | | After |
| 6/28/2010 | TTP | Hughes,P | Traded away | PHR | | After |
| 6/28/2010 | TTP | Jennings | Traded away | RP | | After |
| 6/28/2010 | TTP | Thome | Traded away | RP | | After |
| 6/28/2010 | Ven | Castillo,L | Acquired via trade | PHR | | After |
| 6/28/2010 | Ven | Conrad | Traded away | PHR | | After |
| 6/28/2010 | Ven | Garko | Acquired via trade | PHR | | After |
| 6/28/2010 | Ven | Wuertz | Acquired via trade | PHR | | After |
| 7/1/2010 | DVD | Hill,R | Released | | | Before |
| 7/1/2010 | DVD | Hill,R | Released | | | Before |
| 7/1/2010 | DVD | Hill,R | Signed | | | Before |
| 7/1/2010 | KCR | Treanor | Signed | | | Before |
| 7/1/2010 | MM | Ayala | Signed | | | Before |
| 7/1/2010 | MM | Bale | Signed | | | Before |
| 7/1/2010 | MM | Carlin | Released | | | Before |
| 7/1/2010 | MM | Figueroa | Released | | | Before |
| 7/1/2010 | MM | Richar | Released | | | Before |
| 7/1/2010 | MM | Richar | Signed | | | Before |
| 7/1/2010 | Oak | Blanks | Demoted to reserve roster | | | Before |
| 7/1/2010 | Oak | Brignac | Demoted to reserve roster | | | Before |
| 7/1/2010 | Oak | Clippard | Demoted to reserve roster | | | Before |
| 7/1/2010 | Oak | Davies | Demoted to reserve roster | | | Before |
| 7/1/2010 | Oak | Delgado | Promoted to active roster | | | Before |
| 7/1/2010 | Oak | Escobar,A | Promoted to active roster | | | Before |
| 7/1/2010 | Oak | McCarthy | Demoted to reserve roster | | | Before |
| 7/1/2010 | Oak | Norris | Promoted to active roster | | | Before |
| 7/1/2010 | Oak | Perdomo | Promoted to active roster | | | Before |
| 7/1/2010 | Oak | Volquez | Promoted to active roster | | | Before |
| 7/1/2010 | PHR | Duncan,S | Signed | | | Before |
| 7/1/2010 | PHR | Mayberry | Released | | | Before |
| 7/1/2010 | PHR | Slaten | Signed | | | Before |
| 7/1/2010 | RP | Barfield | Released | | | Before |
| 7/1/2010 | RP | Bixler | Released | | | Before |
| 7/1/2010 | RP | Hall,T | Released | | | Before |
| 7/1/2010 | RP | Jennings | Released | | | Before |
| 7/1/2010 | TTP | Albaladejo | Released | | | Before |
| 7/1/2010 | TTP | Albaladejo | Signed | | | Before |
| 7/1/2010 | TTP | Betemit | Signed | | | Before |
| 7/1/2010 | TTP | Fisher | Signed | | | Before |
| 7/1/2010 | TTP | Lopez,R | Signed | | | Before |
| 7/1/2010 | TTP | Patterson,C | Signed | | | Before |
| 7/1/2010 | TTP | Wise | Signed | | | Before |
| 7/1/2010 | Ven | Everidge | Released | | | Before |
| 7/1/2010 | Ven | Vizcaino | Released | | | Before |
| 7/9/2010 | Oak | Bailey,H | Demoted to reserve roster | | | Before |
| 7/9/2010 | Oak | Sanchez,A | Promoted to active roster | | | Before |
| 7/12/2010 | Oak | Adams,M | Demoted to reserve roster | | | Before |
| 7/12/2010 | Oak | Clippard | Promoted to active roster | | | Before |
| 7/12/2010 | Oak | Delgado | Demoted to reserve roster | | | Before |
| 7/12/2010 | Oak | Duncan,C | Promoted to active roster | | | Before |
| 7/12/2010 | Oak | Swarzak | Promoted to active roster | | | Before |
| 7/12/2010 | Oak | Volquez | Demoted to reserve roster | | | Before |
| 7/17/2010 | Oak | Adams,M | Promoted to active roster | | | Before |
| 7/17/2010 | Oak | Clippard | Demoted to reserve roster | | | Before |
| 8/15/2010 | RP | Aceves | Promoted to active roster | | | Before |
| 8/15/2010 | RP | Cervelli | Promoted to active roster | | | Before |
| 8/15/2010 | RP | Cruz,J | Promoted to active roster | | | Before |
| 8/15/2010 | RP | Karstens | Promoted to active roster | | | Before |
| 8/15/2010 | RP | Marte,D | Promoted to active roster | | | Before |
| 8/15/2010 | RP | Palmer | Promoted to active roster | | | Before |
| 8/15/2010 | RP | Thome | Promoted to active roster | | | Before |